Skyler Conville was last seen just after 1 p.m. Friday at the Circle K near Superstition Blvd. and Meridian Dr.
Conville is a white female, 5 feet 8 inches tall, weighing about 125 pounds, with blue eyes and brown hair.
She was last seen wearing multi-camouflage pants, a dark gray shirt, and a hot pink bonnet.
The teen reportedly had an argument with several family members and walked southbound through the parking lot.
Investigators believe that at that point, she approached and entered what appeared to be an early-2000s white Chevrolet Impala four-door sedan with damage to the front driver-side bumper.