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Thread: The Ebola Epidemic

  1. #51
    Superomnininjamember Monter's Avatar
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    Ebola is a hemorrhagic fever, which disrupts the clotting factors of the blood.
    It only has a 90% fatality rate in third world countries, where there is little supportive care and cultural issues.
    YOU ARE NOT CONTAGIOUS UNTIL YOU ARE SYMPTOMATIC!!

    These are important caveats that differ from movies. It changes the threat level dramatically
    You're entitled to your own opinions. You're not entitled to your own facts.- D. Moynihan
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  2. #52
    Cousin Greg Angiebla's Avatar
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    Quote Originally Posted by Monter View Post
    Ebola is a hemorrhagic fever, which disrupts the clotting factors of the blood.
    It only has a 90% fatality rate in third world countries, where there is little supportive care and cultural issues.
    YOU ARE NOT CONTAGIOUS UNTIL YOU ARE SYMPTOMATIC!!

    These are important caveats that differ from movies. It changes the threat level dramatically
    Ok then it is similar to HGE (hemorrhagic gastroenteritis) in animals. They basically poop blood and bleed out.

    "The love for all living creatures is the most noble attribute of man" -Charles Darwin

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  3. #53
    Senior Member bermstalker's Avatar
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    O/T- Fuck Parvo is terrible. TERRIBLE.

    Back in the 90's my stepdad lost all his hunting dogs. It was terrible to watch. After that, he said we couldn't have any dogs for a long time. Something about how Parvo gets in the ground. I don't know if that's true, but I will always remember how terrible it was when his dog's got parvo. So much blood everywhere. After they all died, we set that piece of land on fire- along with all the dog houses.

  4. #54
    What do you care? Boston Babe 73's Avatar
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    It's SUPER contagious

    That's why I always cringe when I see new dog owners taking their unvaccinated puppies out and about. These days you have the quarantine them until 3 months old and their final shots.
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  5. #55
    Senior Member bermstalker's Avatar
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    Senior Member debk589's Avatar
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    Apparently the guy is already showing signs of improvement:

    Dr. Kent Brantly, a doctor who contracted Ebola in Liberia during a Christian mission and was flown back to the U.S. this past week and appears to be "improving," according to Thomas Frieden who appeared on CBS' Face the Nation on Sunday.

    "It's encouraging that he seems to be improving," Center for Disease Control Director, Thomas Frieden said of the 33 year-old American doctor's health. "That is really important, and we are hoping he will continue to improve."

    According to CNN, Brantly received an experimental dose of serum before leaving Liberia. Upon entering the U.S. for treatment, he became the first person infected with the deadly virus to be cared for in the states. Brantly along with fellow missionary Nancy Writebol, who is expected to arrive on Tuesday, are being treated in a special isolation unit at Emory Hospital in Atlanta. Both contracted the virus while trying to help stop the spread of Ebola in West Africa.

    Brantly's wife Amber told CNN that she was "confident that he is receiving the very best care." She told the news station on Sunday that she "…was able to see Kent today. He is in good spirits. He thanked everyone for their prayers and asked for continued prayer for Nancy Writebol's safe return and full recovery."

    Frieden noted on Face the Nation that although Amber and the couple's daughter saw Dr. Brantly in Libera, "…they did not have contact with him when he was sick, so it does not appear that they would be at risk."
    http://www.theroot.com/articles/cult...?wpisrc=burger



    All I know is that if it were my family member who contracted the disease, I'd absolutely want them here receiving the best possible care.

    I'm scheduled to go to Emory hospital for work next week, and I'm not even the least bit concerned. The only thing I'm worried about is all the media slowing me down, I gots work to do yo!

  7. #57
    Moderator puzzld's Avatar
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    I fully expect that some horrible disease will reduce the Earths population dramatically at some point, like the Spanish flu or the plague. But I don't think Ebola is the one. HIV is much scarier. You can be contagious for years without realizing it, unlike Ebola. All HIV needs to be the next big thing (again) is to figure out how to spread by casual contact...

    But I do sincerely pity the folks dealing with this in Africa.
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  8. #58
    Senior Member TupeloHoney's Avatar
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    Quote Originally Posted by debk589 View Post
    Apparently the guy is already showing signs of improvement:




    All I know is that if it were my family member who contracted the disease, I'd absolutely want them here receiving the best possible care.

    I'm scheduled to go to Emory hospital for work next week, and I'm not even the least bit concerned. The only thing I'm worried about is all the media slowing me down, I gots work to do yo!



    That's wonderful news!

    I went to a party Saturday night just a few miles from both Emory and the CDC. I wasn't feeling too great when I woke up yesterday morning ... at first I thought I had Ebola, but then I realized I just drank way too much Hopsecutioner, hahahaha.



    Seriously though, one of my friends posted on FB that her mom has postponed the surgery she was supposed to have this week at Emory because she's afraid of Ebola. I tried to gently remind her that every time her mom visits her doctor, she's less than a mile from the CDC, which is home to all of the nastiest bugs in the world. Her response was "But why did they have to bring it heeeeere????"

    I guess many people don't realize that, for many years, the virus and numerous animals infected with it have been housed in labs all over the country (and continent).

    It's a frightening illness, but it definitely doesn't help when ignorant people spread lies and misinformation about it.




    Hope you have a nice trip. The traffic is waaaay scarier than the Ebola around here, lol.
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  9. #59
    Superomnininjamember Monter's Avatar
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    Quote Originally Posted by TupeloHoney View Post
    That's wonderful news!

    I went to a party Saturday night just a few miles from both Emory and the CDC. I wasn't feeling too great when I woke up yesterday morning ... at first I thought I had Ebola, but then I realized I just drank way too much Hopsecutioner, hahahaha.



    Seriously though, one of my friends posted on FB that her mom has postponed the surgery she was supposed to have this week at Emory because she's afraid of Ebola. I tried to gently remind her that every time her mom visits her doctor, she's less than a mile from the CDC, which is home to all of the nastiest bugs in the world. Her response was "But why did they have to bring it heeeeere????"

    I guess many people don't realize that, for many years, the virus and numerous animals infected with it have been housed in labs all over the country (and continent).

    It's a frightening illness, but it definitely doesn't help when ignorant people spread lies and misinformation about it.




    Hope you have a nice trip. The traffic is waaaay scarier than the Ebola around here, lol.
    THANK YOU!!
    Concern is understandable - fear mongering and panic is not.
    You're entitled to your own opinions. You're not entitled to your own facts.- D. Moynihan
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  10. #60
    Senior Member TupeloHoney's Avatar
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    Quote Originally Posted by Monter View Post
    THANK YOU!!
    Concern is understandable - fear mongering and panic is not.
    Yeah, people around here start panicking like wildebeests when we have a snowstorm coming, so I figured at least a few people would be losing their minds about the Ebola patients coming to town.

    I found this graphic quite amusing (it's from the epidemiologist's post that Berm shared from the Science Blogs site):

    Quote Originally Posted by Not your business View Post
    I will out think the fucking pants off of you and you would thank me for helping you out of them.

  11. #61
    Moderator puzzld's Avatar
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    Three top secret, experimental vials stored at subzero temperatures were flown into Liberia last week in a last-ditch effort to save two American missionary workers who had contracted Ebola, according to a source familiar with details of the treatment.

    On July 22, Dr. Kent Brantly woke up feeling feverish. Fearing the worst, Brantly immediately isolated himself. Nancy Writebol's symptoms started three days later. A rapid field blood test confirmed the infection in both of them after they had become ill with fever, vomiting and diarrhea.

    It's believed both Brantly and Writebol, who worked with the aid organization Samaritan's Purse, contracted Ebola from another health care worker at their hospital in Liberia, although the official Centers for Disease Control and Prevention case investigation has yet to be released.

    A representative from the National Institutes of Health contacted Samaritan's Purse in Liberia and offered the experimental treatment, known as ZMapp, for the two patients, according to the source.

    The drug was developed by the biotech firm Mapp Biopharmaceutical Inc. The patients were told that this treatment had never been tried before in a human being but had shown promise in small experiments with monkeys.

    According to company documents, four monkeys infected with Ebola survived after being given the therapy within 24 hours after infection. Two of four additional monkeys that started therapy within 48 hours after infection also survived. One monkey that was not treated died within five days of exposure to the virus.

    Brantly and Writebol were aware of the risk of taking a new, little understood treatment; informed consent was obtained from both Americans, according to two sources familiar with the care of the missionary workers. In the monkeys, the experimental serum had been given within 48 hours of infection. Brantly didn't receive it until he'd been sick for nine days.

    The medicine is a three-mouse monoclonal antibody, meaning that mice were exposed to fragments of the Ebola virus and then the antibodies generated within the mice's blood were harvested to create the medicine. It works by preventing the virus from entering and infecting new cells.

    The Ebola virus causes viral hemorrhagic fever, which refers to a group of viruses that affect multiple organ systems in the body and are often accompanied by bleeding.

    Early symptoms include sudden onset of fever, weakness, muscle pain, headaches and a sore throat. They later progress to vomiting, diarrhea, impaired kidney and liver function -- and sometimes internal and external bleeding.

    The ZMapp vials reached the hospital in Liberia where Brantly and Writebol were being treated Thursday morning. Doctors were instructed to allow the vials to thaw naturally without any additional heat. It was expected that it would be eight to 10 hours before the medicine could be given, according to a source familiar with the process.

    Brantly asked that Writebol be given the first dose because he was younger and he thought he had a better chance of fighting it, and she agreed. However, as the first vial was still thawing, Brantly's condition took a sudden turn for the worse.

    Brantly began to deteriorate and developed labored breathing. He told his doctors he thought he was dying, according to a source with firsthand knowledge of the situation.

    Knowing his dose was still frozen, Brantly asked if he could have Writebol's now-thawed medication. It was brought to his room and administered through an IV. Within an hour of receiving the medication, Brantly's condition dramatically improved. He began breathing easier; the rash over his trunk faded away. One of his doctors described the events as "miraculous."

    By the next morning, Brantly was able to take a shower on his own before getting on a specially designed Gulfstream air ambulance jet to be evacuated to the United States.

    Writebol also received a vial of the medication. Her response was not as remarkable, according to sources familiar with the treatment. However, doctors on Sunday administered Writebol a second dose of the medication, which resulted in significant improvement.

    She was stable enough to be evacuated back to the United States and is expected to arrive before noon Tuesday.

    ZMapp has not been approved for human use, and has not even gone through the clinical trial process, which is standard to prove the safety and efficacy of a medication. The process by which the medication was made available to Brantly and Writebol is highly unusual. It may have fallen under the U.S. Food and Drug Administration's "compassionate use" regulation, which allows access to investigational drugs outside clinical trials.

    Getting approval for compassionate use is often long and laborious, but in the case of Brantly and Writebol, they received the medication within seven to 10 days of their exposure to the Ebola virus.

    On July 30, the Defense Threat Reduction Agency, an arm of the military responsible for any chemical, biological, radiological, nuclear and high-yield explosive threats, allotted additional funding to MAPP Biopharmaceutical due to "promising results."
    http://www.cnn.com/2014/08/04/health...html?hpt=hp_t1
    Quote Originally Posted by bowieluva View Post
    lol at Nestle being some vicious smiter, she's the nicest person on this site besides probably puzzld. Or at least the last person to resort to smiting.
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  12. #62
    Senior Member Mars Defense Perimeter's Avatar
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    Quote Originally Posted by puzzld View Post
    Three top secret, experimental vials stored at subzero temperatures were flown into Liberia last week in a last-ditch effort to save two American missionary workers who had contracted Ebola, according to a source familiar with details of the treatment.


    ZMapp has not been approved for human use, and has not even gone through the clinical trial process, which is standard to prove the safety and efficacy of a medication. The process by which the medication was made available to Brantly and Writebol is highly unusual. It may have fallen under the U.S. Food and Drug Administration's "compassionate use" regulation, which allows access to investigational drugs outside clinical trials.

    Getting approval for compassionate use is often long and laborious, but in the case of Brantly and Writebol, they received the medication within seven to 10 days of their exposure to the Ebola virus.

    Don't forget the hidden subtext of this story: "And all the hundreds of poor, gross, nonwhite Africans who died horrible deaths didn't get jack shit. And that's why it's awesome to be an American."

  13. #63
    Senior Member bermstalker's Avatar
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    Quote Originally Posted by Trazodone Uprising View Post
    Don't forget the hidden subtext of this story: "And all the hundreds of poor, gross, nonwhite Africans who died horrible deaths didn't get jack shit. And that's why it's awesome to be an American."

    You know what? You're right.

    Man, that's tucked up if you think about it. All those people that are dying from the virus and there is already a *possible* cure but only 3 people get it. WTF?

  14. #64
    Moderator puzzld's Avatar
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    I wondered which assholes would be the first to bring that up.

    Let me quote:
    ZMapp has not been approved for human use, and has not even gone through the clinical trial process, which is standard to prove the safety and efficacy of a medication. The process by which the medication was made available to Brantly and Writebol is highly unusual. It may have fallen under the U.S. Food and Drug Administration's "compassionate use" regulation, which allows access to investigational drugs outside clinical trials.

    Getting approval for compassionate use is often long and laborious, but in the case of Brantly and Writebol, they received the medication within seven to 10 days of their exposure to the Ebola virus.

    On July 30, the Defense Threat Reduction Agency, an arm of the military responsible for any chemical, biological, radiological, nuclear and high-yield explosive threats, allotted additional funding to MAPP Biopharmaceutical due to "promising results."
    http://www.cnn.com/2014/08/04/health...html?hpt=hp_t1
    This is a brand new, untested treatment. To give it to humans at all would generally be considered highly unethical. Only the fact that this disease is so deadly makes it marginally OK to give it to people who are able to give informed consent. We have no idea what the long term risk factors are. Maybe there are none. Maybe it will cause kidney failure, heart attacks, cancer. We just don't know. Only the fact that these two were able to say yes. I understand the risks makes this OK. If anything bad happens to either of these patients? I expect heads will roll. It's all very irregular.
    Quote Originally Posted by bowieluva View Post
    lol at Nestle being some vicious smiter, she's the nicest person on this site besides probably puzzld. Or at least the last person to resort to smiting.
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  15. #65
    Senior Member bermstalker's Avatar
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    I would figure the health officials would try an unapproved drug out on poor people in Africa instead of the 3 they picked.

    I do wonder why they decided to test it out on these 3? Nothing wrong with it, just wondering their process in picking out untested/untried drugs.

    It reminds of an article I read the other day about this new wonder drug for Hep C patients. The article was talking about how one man had to fight to get his insurance company to cover it- it was 83,000 ( I think) for just 3 treatments.

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    Senior Member queenaevadamthng's Avatar
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    It seems like they could have at least tried the ZMapp in the experimental phase to those that would have agreed. I don't want to sound cold but this disease has a very low survival rate. If the vaccine didn't work, the test subjects would have died anyway, but at least scientists would have had the data. Many lives could have been saved up until now. With that being said, is it a possibility that the 10% that did survive may have been unknowing test subjects? Unauthorized governmental testing on humans isn't unheard of.
    Last edited by queenaevadamthng; 08-04-2014 at 02:37 PM.


    "Theoretical physics can prove that an elephant can hang from a cliff with its tail tied to a daisy. But use your eyes, your common sense".... JIM GARRISON

  17. #67
    What do you care? Boston Babe 73's Avatar
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    Quote Originally Posted by queenaevadamthng View Post
    Unauthorized governmental testing on humans isn't unheard of.
    This.

    And since when has our government been ethical?
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  18. #68
    Senior Member Mars Defense Perimeter's Avatar
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    Quote Originally Posted by puzzld View Post
    I wondered which assholes would be the first to bring that up.

    Let me quote:


    This is a brand new, untested treatment. To give it to humans at all would generally be considered highly unethical. Only the fact that this disease is so deadly makes it marginally OK to give it to people who are able to give informed consent. We have no idea what the long term risk factors are. Maybe there are none. Maybe it will cause kidney failure, heart attacks, cancer. We just don't know. Only the fact that these two were able to say yes. I understand the risks makes this OK. If anything bad happens to either of these patients? I expect heads will roll. It's all very irregular.
    Well get out your asshole crayon and color me an asshole.

    I get where you're coming from. But look at the alternative to not trying the unapproved drug--you're pretty much fucked, right? Especially if you're in Liberia or wherever the hell it is. If this treatment falls under 'compassionate use', I doubt anyone will be held liable should the drug effects go bad. All I'm saying is that it is pretty shitty that some Americans get first crack at the treatment when there are plenty of suffering Africans who could very easily give informed consent. Maybe the intention wasn't to look like a bunch of first world racist assholes. Maybe it just boils down to 'hey, these are our people--if we're going to kill anyone with drugs, let's kill them first.' But I can't imagine how this looks to the rest of the world. Americans get sick in a plague zone, get flown home, get special treatment--while scores of Africans keep dying. It's not an unreasonable observation to make.

  19. #69
    Senior Member Mars Defense Perimeter's Avatar
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    Quote Originally Posted by queenaevadamthng View Post
    It seems like they could have at least tried the ZMapp in the experimental phase to those that would have agreed.
    I couldn't imagine what the reason$ for that might be.

  20. #70
    Superomnininjamember Monter's Avatar
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    You know what will solve all this? Tin foil. Lots and lots if tin foil...
    You're entitled to your own opinions. You're not entitled to your own facts.- D. Moynihan
    Quote Originally Posted by aquatwins View Post
    I WILL STICK MY DICK IN YOUR HEAD

  21. #71
    Moderator puzzld's Avatar
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    Quote Originally Posted by Monter View Post
    You know what will solve all this? Tin foil. Lots and lots if tin foil...
    I'm gonna buy stock.
    Quote Originally Posted by bowieluva View Post
    lol at Nestle being some vicious smiter, she's the nicest person on this site besides probably puzzld. Or at least the last person to resort to smiting.
    Quote Originally Posted by nestlequikie View Post
    Why on earth would I smite you when I can ban you?

  22. #72
    Senior Member blighted star's Avatar
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    Nope. Buy stock in tobacco!!

    http://www.kentucky.com/2014/08/04/3.../99/322/&ihp=1




    The drug being credited with potentially saving the lives of two American missionaries infected with the deadly Ebola virus was produced at a facility in Owensboro. The serum wasn't manufactured but grown, in a greenhouse full of genetically modified tobacco plants. Kentucky BioProcessing, acquired by Reynolds American in January, conducts contract research and development for San Diego-based Mapp Biopharmaceutical, said David Howard, spokesman for RAI Ser vices, a subsidiary of Reynolds American.

    "In the last week, Kentucky BioProcessing complied with a request from Emory University and Samaritan's Purse to provide a very limited amount (of the compound) to Emory, and KPB has done that," Howard said. CNN and NBC News reported Monday that ZMapp had been given to Dr. Kent Brantly and Nancy Writebol, who have been described as showing significant improvement. The experimental drug apparently had never been tested on humans.

    In 2007, Mapp, working under contract for the U.S. Department of Defense and other federal agencies, engaged KBP to develop a process to manufacture a compound designed to be a post-exposure treatment for Ebola virus. That compound was MB-003 or ZMapp, a cocktail of antibodies that has proven to be the most effective treatment so far in fighting off the Ebola virus. In a study published last year, scientists at the U.S. Army Medical Research Institute of Infectious Diseases reported that 43 percent of infected nonhuman primates recovered after receiving the treatment intravenously 104 to 120 hours after infection ? after symptoms developed.

    "Mapp Biopharmaceutical has the structure of this protein to battle the Ebola. And KPB is building that protein," Howard said. In Owensboro, tobacco plants are "infected" with the protein, he said, and then they reproduce it "like a photocopier." The desired proteins are extracted from the plants and purified into a serum. Scientists have long known that tobacco readily picks up genes inserted into it. The Owensboro facility uses that ability to quickly and inexpensively produce large volumes of a compound within weeks.

    KBP also has been selected for work on some of the biggest health threats on the planet, including H1N1 vaccine production, an anti-rabies antibody, norovirus or the "cruise ship virus," HIV prevention, parvovirus, and HPV vaccine. ZMapp, the drug used on the American Ebola victims, has not been approved in the United States or other countries, Howard said, but the Owensboro facility had begun ramping up production for anticipated drug approval testing protocols this year. That process might be accelerated now. "KBP is working closely with Mapp and other agencies to increase production, but that process will take several months," Howard said.
    & as bad as it looks releasing an experimental lifesaving drug for U.S citizens only, can you imagine the outcry if they had mass-released it to uninformed, poverty-stricken populations in some of the most disadvantaged areas of the planet?

    No-one would believe they'd done it for humanitarian reasons & they'd be savaged in the media & medical journals.

    Drug companies have a dark, dark history when it comes to this sort of shit. They don't want to be associated with it anymore

    http://rense.com/general36/history.htm

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    Senior Member blighted star's Avatar
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    Dbl post


    Oops. Sorry. My new tablet just did something freaky.

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    Quote Originally Posted by puzzld View Post
    I'm gonna buy stock.
    Yup! Reynolds Aluminum = R.J. Reynolds Tobacco = Reynolds America

    The tin foil people are growing the medical tobacco. They had to find some use for it, ya know.

    I thought it was only Brantly and Writebol who got the drug. Who is this 3rd person?

    I think they were able to bypass a lot of red tape to get the drug because they were out of country. The FDA has no jurisdiction in Liberia. Liberian government would have to approve it for its citizens, I think.

  25. #75
    Senior Member Mars Defense Perimeter's Avatar
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    Quote Originally Posted by The Crone View Post
    I think they were able to bypass a lot of red tape to get the drug because they were out of country. The FDA has no jurisdiction in Liberia. Liberian government would have to approve it for its citizens, I think.
    Stupid good point. But still, you think the UN could---ahahahaha I couldn't even finish that sentence.

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