CAMPBELLTOWN City police are making an urgent appeal for information to find missing man Justin Moule, who disappeared two days ago.

Mr Moule, 21, was last seen by his family in the Campbelltown area on Wednesday about 4.30pm.

Campbelltown City police said Mr Moule's family were concerned for his wellbeing and had reported him missing.

"Both family and police do not believe Justin has access to a vehicle, so (he) may be using public transport to get around,'' Campbelltown City police said on their Facebook page.

Train and bus commuters are being urged to help find Mr Moule.

Mr Moule is about 183cm tall, with a slim build and sandy brown hair.

Anyone with information about Mr Moule's whereabouts is urged to contact Campbelltown City police on 4620 1199 or Crime Stoppers on 1800 333 000.